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Home > Products >  Factory Direct Sale Succimer Cas 304-55-2

Factory Direct Sale Succimer Cas 304-55-2 CAS NO.304-55-2

  • FOB Price: USD: 10.00-10.00 /Metric Ton Get Latest Price
  • Min.Order: 1 Kilogram
  • Payment Terms: T/T,MoneyGram,Other
  • Available Specifications:

    High(1-1000)Metric Ton

  • Product Details

Keywords

  • 304-55-2
  • Succimer
  • C4H6O4S2

Quick Details

  • ProName: Factory Direct Sale Succimer Cas 304-5...
  • CasNo: 304-55-2
  • Molecular Formula: C4H6O4S2
  • Appearance: White Powder
  • Application: Pharmaceutical intermediates
  • DeliveryTime: With in 15days
  • PackAge: 25kg/bag,1kg/bag
  • Port: Tianjin
  • ProductionCapacity: 10000000 Metric Ton/Day
  • Purity: 99%
  • Storage: Store in cool & dry ,ventilated
  • Transportation: Express/sea/air
  • LimitNum: 1 Kilogram
  • Impurity: <0.01

Superiority

Product Name: Succimer
Synonyms: (2R,3S)-2,3-diMercaptosuccinic acid;(2R,3S)-rel-2,3-DiMercaptosuccinic acid;Butanedioic acid,2,3-diMercapto-, (2R,3S)-rel-;meso-2,3-Dimercaptosuccinic acid;API Succimer;-rel-2,3-Dimercaptosuccinic acid;(2S,3R)-2,3-dimercaptobutanedioate;(r*,s*)-2,3-dimercaptobutanedioicacid
CAS: 304-55-2
MF: C4H6O4S2
MW: 182.22
EINECS: 206-155-2
Product Categories: API;Inhibitors;Organic acids;Analytical Chemistry;Ligands for Pharmaceutical Research;Radiopharmaceutical Chemistry (Chelating Reagents);Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfur Compounds;Thiols/Mercaptans
Mol File: 304-55-2.mol
Succimer Structure
 
Succimer Chemical Properties
Melting point  196-198 °C (dec.)(lit.)
Boiling point  285.62°C (rough estimate)
density  1.439 (estimate)
refractive index  1.5220 (estimate)
storage temp.  -20°C
pka pK1:2.71;pK2:3.48;pK3:8.89(SH);pK4:10.79(SH) (25°C)
form  Powder
color  White to off-white
Water Solubility  Soluble in water, and ethanol (25 mg/ml, results in colorless to light yellow, clear).
Merck  14,8865
BRN  1725150
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey ACTRVOBWPAIOHC-XIXRPRMCSA-N
CAS DataBase Reference 304-55-2(CAS DataBase Reference)
EPA Substance Registry System Butanedioic acid, 2,3-dimercapto-, (2R,3S)-rel- (304-55-2)
 

Details

Description Succimer is a newly available oral chelator of lead and other heavy metals. The compound is indicated for the treatment of lead poisoning in children. Succimer does not bind iron, calcium or magnesium and preferentially binds lead, mercury and arsenic over copper or zinc. The metal-bound succimer is excreted in the urine. The drug may also be effective in adults.
Chemical Properties white or off-white powder
Originator Johnson and Johnson (J&J) (U.S.A.)
Uses A selective masking agent for cadmium in EDTA titration of zinc.
Uses chelating agent, antihypertensive
Uses meso-2,3-Dimercaptosuccinic Acid is used as a chelating agent and masking agent for cadmium in EDTA titration of zinc.
Uses chelating agent, treatment of lead poisoning
Uses A water-soluble chelating agent.
Uses Chelating agent.
Definition ChEBI: A sulfur-containing carboxylic acid that is succinic acid bearing two mercapto substituents at positions 2 and 3. A lead chelator used as an antedote to lead poisoning.
Brand name Chemet (Ovation).
Pharmaceutical Applications Dimercaptosuccinic acid (DMSA) is a modification of BAL containing two thiol groups, which are responsible for the unpleasant smell, and two carboxylic acid groups. DMSA is also known under the name Succimer. It chemical name is meso-2,3-dimercaptosuccinic acid and the chemical formula is HO2CCH(SH)CH(SH)CO2H. There are two diastereomeric forms, meso and the chiral DL forms, with the meso isomer being used as chelating agent.
DMSA was developed in the 1960s and replaced BAL and edetate in some countries for the treatment of lead, arsenic and mercury poisoning. Furthermore, the dimethylester modification of DMSA has been successfully used for the treatment of heavy-metal poisoning.
Pharmaceutical Applications The unlicensed drug Succimer (DMSA, meso-2,3-dimercaptosuccinic acid) may be valuable in the treatment of most forms of heavy-metal poisoning including lead, arsenic and mercury. These and other chelating agents such as unithiol (DMPS, 2,3-dimercapto-1-propanesulfonic acid) and α-lipoic acid (ALA) are also used in alternative medicine, which has led to much criticism and discussion. So far, no medical study has proven the effectiveness of chelation therapy for any clinical application other than heavy-metal poisoning.

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